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Best Doctor List Near You for Chordoma In Orthopedic Surgery in Sao bernardo do campo
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Chordoma is a rare type of malignant bone tumor that primarily arises from the remnants of the notochord, a structure that contributes to the development of the spinal column and the vertebral bodies during embryonic stages. These tumors most commonly occur in the axial skeleton, particularly at the base of the skull and in the sacrococcygeal region, but can also manifest in the thoracic and lumbar spine. While chordomas are often slow-growing, they are notorious for being locally aggressive and can invade surrounding structures, leading to significant morbidity. The exact cause of chordoma remains unclear; however, genetic mutations, particularly involving the Brachyury gene, are believed to play a crucial role in their development. This gene is a crucial transcription factor involved in notochord formation and is often found to be overexpressed in chordoma tissues. In terms of demographics, chordomas are more frequently diagnosed in adults, typically between the ages of 30 and 60, with a slight male predominance. Symptoms of chordoma depend on the tumor's location and size; for example, sacral chordomas may cause lower back pain, altered bowel habits, and neurological deficits due to compression of nearby structures, while cranial chordomas may present with headaches, vision problems, or cranial nerve dysfunction. Diagnosis involves imaging techniques such as MRI or CT scans, which can reveal the characteristic features of a chordoma, including its aggressive growth pattern and involvement of adjacent tissues. A biopsy is often necessary to confirm the diagnosis, as the histological appearance of chordomas is distinctive, featuring a mix of physaliferous cells and a myxoid stroma. Treatment for chordoma typically involves surgical resection, with the goal of achieving clear margins to reduce the likelihood of recurrence. However, complete resection can be challenging due to the tumor's invasive nature and its location near critical structures. In cases where surgical margins cannot be achieved, adjuvant radiation therapy, including proton beam therapy or conventional radiation, may be utilized to target residual tumor cells. Despite treatment, chordomas can recur, and long-term surveillance is essential for early detection of recurrence. The prognosis for chordoma patients varies, with survival rates generally being lower compared to more common bone tumors, often reflecting the tumor's location and the extent of surgical resection. Recent advancements in genetic and molecular research hold promise for more targeted therapies and improved outcomes in the future. Overall, chordoma remains a complex challenge in the field of orthopedic surgery, requiring an interdisciplinary approach for optimal management and care of affected individuals.
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